High molecular weight major outer membrane protein of moraxella

Details High molecular weight major outer membrane protein of moraxella High molecular weight major outer membrane protein of moraxella

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/70 (2006.01) A61K 39/02 (2006.01) A61K 39/116 (2006.01) A61K 39/295 (2006.01) A61K 39/385 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/195 (2006.01) C07K 14/21 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2219889

An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

La présente invention concerne une protéine, isolée et purifiée, de membrane externe d'une souche de Moraxella, en particulier M. catarrhalis, ayant une masse moléculaire d'environ 200 kDa. Cette protéine de membrane externe d'environ 200 kDa et des molécules d'acide nucléique qui la codent sont utiles dans les applications en diagnostic et dans les compositions immunogéniques, en particulier pour l'administration in vivo à un hôte afin de conférer une protection contre la maladie causée par un germe bactérien pathogène qui produit la protéine en question ou une protéine capable de provoquer la production d'anticorps dans un hôte qui soit réactif de manière spécifique à la protéine de membrane externe d'environ 200 kDa.

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