High molecular weight polymer-based prodrugs

Details High molecular weight polymer-based prodrugs High molecular weight polymer-based prodrugs

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/335 (2006.01) A61K 31/47 (2006.01) A61K 31/77 (2006.01) A61K 38/00 (2006.01) C07D 305/14 (2006.01) C07D 405/12 (2006.01) C07D 491/22 (2006.01)

Patent

CA 2208841

High molecular weight, water-soluble prodrugs of formula (I), wherein: D is a biologically active moiety; M is X or Q; X is an electron withdrawing group; Q is a moiety containing a free electron pair positioned five or six atoms from Y'; Y and Y' are oxygen or sulfur; and R is a polyalkylene oxide, are disclosed. Methods of preparing the compounds as well as methods of treatment using the compounds are also disclosed.

Promédicaments solubles dans l'eau, ayant un poids moléculaire élevé, de formule (I) dans laquelle D est une fraction biologiquement active; M représente X ou Q; X est un groupe de retrait d'électrons; Q est une fraction contenant une paire d'électrons libres positionnée à 5 ou 6 atomes par rapport à Y'; Y et Y' représentent oxygène ou soufre; et R est un oxyde de polyalkylène. Des procédés de préparation de ces composés ainsi que des procédés de traitement à l'aide de ces composés sont également décrits.

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