High penetration compositions and their applications

Details High penetration compositions and their applications High penetration compositions and their applications

A - Human Necessities

61

K

A61K 31/00 (2006.01)

Patent

CA 2745206

High penetration compositions (HPC) of a parent compound, which are capable of crossing biological barriers with high penetration efficiency. The HPCs are capable of being converted to parent drugs or parent drug-related compounds such as metabolites after crossing one or more biological barriers and thus can render treatments for the conditions that the parent drugs or parent drug-related compounds can. Additionally, the HPCs are capable of reaching areas that their parent drugs or parent drug-related compounds may not be able to access or to render a sufficient concentration at the target areas HPCs of NSAIA, for example, have demonstrated indications such as treating hair loss. A HPC can be administered to a subject through various administration routes, e. g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

Linvention concerne des compositions à pénétration élevée (HPC) dun composé parent, qui sont capables de traverser des barrières biologiques par pénétration efficace élevée. Les HPC peuvent être tranformées en médicaments parents ou en composés apparentés à des médicaments parents, tels que des métabolites, après passage dune ou plusieurs barrières biologiques, ce qui  produit des traitement pour des états que les médicaments parents ou les composés apparentés à des médicaments parents peuvent traiter. Les HPC peuvent également atteindre des zones que leurs médicaments parents ou leurs composés apparentés à des médicaments parents ne peuvent atteindre ou produire une concentration suffisante au niveau des zones cibles HPC de NSAIA. Les HPC ont montré, par exemple des indications telles que le traitement de la chute des cheveux. Une HPC peut être administrée à un sujet via des voies dadministration variées, par exemple, localement à un site daction sur un état à une concentration élevée ou de manière systémique à un sujet biologique et entrer dans la circulation générale plus rapidement.

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