High potency dopaminergic treatment of neurological...

A - Human Necessities – 61 – K

Patent

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A61K 31/473 (2006.01) A61K 31/198 (2006.01) A61K 31/454 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2519117

Methods and compositions are described for treating impaired neurological function, including altered state of consciousness disorders, in an individual who has sustained a brain injury comprising administering to the individual apomorphine. Methods and compositions are described for treating impaired neurological function, including altered state of consciousness disorders, in an individual who has sustained a brain injury comprising administering to the individual at least 1000mg or more of L-dopa (levodopa) per day. The use of potent dopaminergic agents to stimulate emergence form an altered consciousness state, such as a coma, is disclosed.

L'invention porte sur des méthodes et compositions de traitement de fonctions neurologiques déficientes dont des troubles d'altération de l'état de conscience chez un patient ayant subi une lésion du cerveau, consistant à lui administrer de l'apomorphine, et sur des méthodes et compositions de traitement de fonctions neurologiques déficientes dont des troubles d'altération de l'état de conscience chez un patient ayant subi une lésion du cerveau, consistant à lui administrer quotidiennement au moins 1000 mg ou plus de L-dopa (lévodopa). L'invention porte également sur l'utilisation de ces agents pour stimuler l'émergence hors d'un état de conscience altéré tel que le coma.

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