High pressure spray-dry of bioactive materials

Details High pressure spray-dry of bioactive materials High pressure spray-dry of bioactive materials

C - Chemistry, Metallurgy

12

N

C12N 9/98 (2006.01) A61K 9/127 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2508592

This invention provides compositions and methods providing, e.g., stable powder particles containing bioactive materials. The methods include, e.g., high pressure spraying of the bioactive materials in solution or suspension, with viscosity enhancing agents and/or surfactants. Compositions of the invention provide, e.g., high initial purity, high stability in storage, and reconstitution at high concentrations.

L'invention concerne des compositions et des procédés permettant d'administrer notamment des particules en poudre stables renfermant des matériaux bioactifs. La démarche consiste à vaporiser sous haute pression des matériaux bioactifs en solution ou en suspension conjointement avec des agents améliorant la viscosité et/ou des tensioactifs. Les compositions de l'invention présentent notamment une grande pureté initiale, une stabilité élevée au stockage et une faculté de reconstitution à des concentrations élevées.

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