High pressure spray-dry of bioactive materials

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61J 3/02 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2564791

This invention provides compositions and methods providing, e.g., stable powder particles containing bioactive materials. The methods include, e.g., high pressure spraying of the bioactive materials in solution or suspension, with viscosity enhancing agents, organic solvents, and/or surfactants. Formulations are provided for spraying therapeutic bioactive materials into powder particles containing amino acids and sugars. Compositions of the invention provide, e.g., high initial purity, high stability in storage, and reconstitution at high concentrations.

L'invention concerne des compositions et des procédés qui permettent d'obtenir, par exemple, des particules pulvérisées stables qui renferment des substances bioactives. Ces procédés consistent à pulvériser à haute pression des substances bioactives en solution ou en suspension, conjointement avec des agents d'amélioration de viscosité, des solvants organiques, et/ou des tensioactifs. Des formulations sont prévues pour pulvériser des substances thérapeutiques bioactives sous forme de particules pulvérisées qui renferment des acides aminées et des sucres. Les compositions de l'invention sont caractérisées par une pureté initiale élevée, une stabilité élevée au stockage ainsi qu'une aptitude à la reconstitution à des concentrations élevées.

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