C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/12 (2006.01) A61K 31/13 (2006.01) A61P 25/22 (2006.01) C07C 213/02 (2006.01) C07C 217/02 (2006.01)
Patent
CA 2369393
The invention relates to high purity (1R,2S,4R)-(-)-2- [(2'-{N,N- dimethylamino} -ethoxy)] -2-[phenyl] -1,7,7-tri-[methyl] -bicyclo[2.2.1] heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2 % of (1R,3S,4R)-3- [(2'-{N,N- dimethylamino} -ethyl)]-1,7,7- tri- [methyl] -bicyclo [2.2.1] heptane-2-one and/or of a pharmaceutically acceptable acid addition salt thereof. Furthermore the invention is concerned with a process for the preparation of these compounds. Moreover the invention relates to medicaments containing 1 or more of these compounds and their use.
Cette invention concerne (1R,2S,4R)-(-)-2- [(2'-{N,N- diméthylamino} -éthoxy)]-2- [phényle] -1,7,7-tri- [méthyle] -bicyclo [2.2.1]heptane et des sels d'addition acides pharmaceutiquement acceptable de ceux-ci ne contenant pas plus de 0.2 % de (1R,3S,4R)-3- [(2'-{ N,N-diméthylamino} -éthyle)] -1,7,7-tri- [méthyle]- bicyclo[2.2.1] heptane-2-one et/ou un sel d'addition pharmaceutiquement acceptable de ceux-ci. Cette invention concerne aussi un processus de préparation de ces composés. Elle concerne en outre des médicaments contenant un ou plusieurs de ces composés et leur utilisation.
Budai Zoltan
Krasznai Gyorgy
Lukacs Gyula
Mezei Tibor
Nagy Kalman
Egis Gyogyszergyar Rt.
Robic
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