C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 1/00 (2006.01) A61K 9/20 (2006.01) A61K 31/567 (2006.01)
Patent
CA 2344686
The invention pertains to a process for the preparation of a high purity composition of (7.alpha.,17.alpha.)- 17-hydroxy- 7-methyl- 19-nor-17-pregn- 5(10)-en-20-yn-3-one. The process provides for a composition with less than 0.5 % of (7.alpha.,17.alpha.)- 17-hydroxy- 7-methyl- 19-nor-17-pregn- 4-en-20-yn- 3-one. This composition can be used as a source for the preparation of stable pharmaceutical dosage units.
Cette invention a trait à un procédé de préparation d'une composition à degré élevé de pureté renfermant (7 alpha ,17 alpha )-17-hydroxy-7-méthyl-19-nor-17-pregn-5(10)-en-20-yn-3-one. Il est produit, dans le cadre de ce procédé, une composition renfermant moins de 0,5 % de (7 alpha ,17 alpha )-17-hydroxy-7-méthyl-19-nor-17-pregn-4-en-20-yn-3-one. On peut utiliser cette composition aux fins de la préparation d'unités posologiques pharmaceutiques stables.
Kirchholtes Peter Huub Gerard Maria
Sas Gerard Arnoud Jozef Maria Theresia
Akzo Nobel N.v.
Fetherstonhaugh & Co.
N.v. Organon
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