C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/15 (2006.01) A61P 31/04 (2006.01) C07K 1/16 (2006.01) C07K 1/36 (2006.01) C07K 14/36 (2006.01)
Patent
CA 2398726
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of <i>Streptomyces roseosporus</i>. The invention also discloses high pressure liquid chromatography methods for analysis of daptomycin purity. The invention also discloses lipopeptide micelles and methods of making the micelles. The invention also discloses methods of using lipopeptide micelles for purifying lipopeptide antibiotics, such as daptomycin. The invention also discloses using lipopeptide micelles therapeutically.
La présente invention concerne une daptomycine hautement purifiée et des compositions pharmaceutiques renfermant ce composé. L'invention se rapporte à un procédé de purification de la daptomycine, qui comprend les étapes séquentielles de chromatographie par échange anionique, chromatographie hydrophobe et chromatographie par échange anionique. L'invention concerne également un procédé de purification de la daptomycine par chromatographie par échange anionique modifiée par adjonction d'un tampon. L'invention se rapporte aussi à un procédé amélioré permettant de produire de la daptomycine par fermentation de <i>Streptomyces roseosporus</i>. L'invention concerne des procédés de chromatographie liquide haute pression permettant d'analyser la pureté de la daptomycine. L'invention se rapporte à des micelles de lipopeptides et à des procédés de fabrication des micelles. L'invention concerne des procédés selon lesquels on utilise les micelles de lipopeptides pour purifier des antibiotiques lipopeptidiques, tels que la daptomycine. L'invention concerne enfin l'utilisation thérapeutique des micelles de lipopeptides précitées.
Decourcey Joseph P.
Kelleher Thomas J.
Lai Jan-Ji
Lynch Paul D.
Tagliani Auro R.
Cubist Pharmaceuticals Inc.
Smart & Biggar
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