High specific activity labeled substances

Details High specific activity labeled substances High specific activity labeled substances

G - Physics

01

N

167/37, 260/506

G01N 33/53 (2006.01) C07C 51/00 (2006.01) C07C 53/00 (2006.01) C07C 55/00 (2006.01) C07C 57/00 (2006.01) C07C 59/00 (2006.01) C07C 61/00 (2006.01) C07C 63/00 (2006.01) C07C 65/00 (2006.01) G01N 33/50 (2006.01) G01N 33/532 (2006.01)

Patent

CA 1107644

ABSTRACT OF THE DISCLOSURE A new diagnostic labeled spine tool is disclosed for use in immunoassay technique, e.g., determination of a compo- nent of the antigen-antibody reaction. The new tool is a labeled- spine material product of the formula: (XVI) Image where R is an organic group labeled with a radioisotope, fluores- cent group, lysis-initiating compound, enzyme, pr other suitable marker material; T1 and T2 are any of -CH3, Image , Image , -CH2OH, -CH?SH, and -NH2; X is selected from the group consisting of (CH2)m. where m is an integer from 0 to about 10, phenylene, hydroxyl- substituted phenylene, halogen-substituted phenylene, alkyl sub- stituted phenylene or aminated phenylene groups; a is 0, 1 or 2; b is 2-a, with the proviso that there be at least two R groups in the product; and n is a number from 1 to about 100,000 The new tool provides higher specific activity for labeled sub- stances thus facilitating determination of the desired compound. Preferably R is an enzyme, a is one, and X is of the formula (CH2)m, where m is from 2 to 5.

308130

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