High temperature method for the production of ribavirin

Details High temperature method for the production of ribavirin High temperature method for the production of ribavirin

C - Chemistry, Metallurgy

12

P

195/120

C12P 19/28 (2006.01) C12P 19/38 (2006.01)

Patent

CA 1297058

-0- HIGH TEMPERATURE METHOD FOR THE PRODUCTION OF RIBAVIRIN ABSTRACT of the Disclosure A method for the production of a. 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation deriued from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine and the temperature during at least a part of the reaction is at or above 65°C. The method is capable of high production rates and high concentrations of the final product.

571667

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