C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/81 (2006.01)
Patent
CA 2741190
A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity.
L'invention concerne un procédé de dosage d'un composé qui module les activités de la dipeptidylpeptidase I (DPPI), comprenant les étapes consistant à ajouter un substrat peptidique de DPPI dans un mélange réactionnel qui comprend DPPI et un composé, ledit substrat peptidique de DPPI possédant au moins 3 acides aminés et se liant à un site de liaison de DPII en plus du site S1-S2; et à mesurer la masse moléculaire du substrat, une modification de la masse moléculaire du substrat indiquant la présence d'une activité DPPI.
Olson Matthew
Todd Matthew
Johnson & Johnson Pharmaceutical Research & Development L.l.c.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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