High throughput hplc method for determining log p values

Details High throughput hplc method for determining log p values High throughput hplc method for determining log p values

G - Physics

01

N

G01N 30/02 (2006.01) G01N 30/88 (2006.01) G01N 30/34 (2006.01) G01N 30/89 (2006.01)

Patent

CA 2314878

Methods for calculating Log P values for organic compounds are disclosed. The methods allow identification of compounds in a library with a desired Log P value. The method can be used to minimize the number of compounds in a given combinatorial or lead generation library which need to be further characterized and/or assayed. The Log P value is preferably obtained while the purity of the compounds is being determined. Preferably, the Log P value is correlated to the retention time on an HPLC column, such that the retention time equals the Log P value.

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