High throughput screening by measurement of intracellular...

Details High throughput screening by measurement of intracellular... High throughput screening by measurement of intracellular...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 15/09 (2006.01) C12Q 1/66 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2402693

The present invention provides assays in which intracellular chelators are used to alter the kinetics of signal genera-tion triggered by divalent cations, particularly calcium influx into the cell. The use of an intracellular chelator in the assay can delay and prolong the signal, allowing the signal to be detected by automated instrumentation without the need for simultaneous liquid handling at the time of detection.

La présente invention concerne des dosages dans lesquels des chélateurs intracellulaires sont utilisés pour modifier la cinétique de génération de signal déclenchée par des cations divalents, notamment l'afflux de calcium dans la cellule. L'utilisation d'un chélateur intracellulaire dans le dosage peut retarder et prolonger le signal, permettant de détecter le signal par une instrumentation automatique sans la nécessité d'une manipulation simultanée de liquide au moment de la détection.

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