C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C12N 15/78 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2729839
Methods of identifying and expressing an antibody variant are disclosed wherein the method comprises identifying a binding region in an antibody, fusing the binding region to a plurality of scaffolds of antibody constant regions to obtain antibody fragment variants, expressing the antibody fragment variants in organisms to form constructs and expressing the constructs carried by the organisms to form induced cultures, wherein the organisms are expressed in HTP mode.
La présente invention concerne des procédés d'identification et d'expression d'un variant d'anticorps, le procédé comprenant les étapes consistant à identifier une région de liaison dans un anticorps, relier la région de liaison à une pluralité de structures de régions constantes d'un anticorps afin d'obtenir des variants de fragments d'anticorps, exprimer les variants de fragments d'anticorps dans des organismes afin de former des constructions et exprimer les constructions portées par les organismes afin de former des cultures induites, les organismes étant exprimés dans le mode HTP.
Gowling Lafleur Henderson Llp
Pfenex Inc.
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