High-throughput screening of compounds using electrospray...

Details High-throughput screening of compounds using electrospray... High-throughput screening of compounds using electrospray...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2325253

A high-throughput screening system employing electrospray ionization mass spectrometry (ESI-MS) to investigate the interactions of between small molecules and polynucleotides and monitor small molecule:polynucleotide complexes, thereby allowing valid mechanistic interactors to be distinguished from false positive signals. ESI- MS may also be used as an early-stage toxicity screening tool.

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