High throughput screening of crystallization of materials

Details High throughput screening of crystallization of materials High throughput screening of crystallization of materials

B - Operations, Transporting

29

C

B29C 39/00 (2006.01) B01L 3/00 (2006.01) B01L 9/00 (2006.01) B29C 45/00 (2006.01) B81B 3/00 (2006.01) B81C 1/00 (2006.01) C30B 35/00 (2006.01) B01L 7/00 (2006.01)

Patent

CA 2442914

High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers (9102a, 9102b) of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers (9102a, 9102b), thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

L'invention porte sur le criblage à haut rendement de la cristallisation d'un matériau cible qui s'effectue par introduction simultanée d'une solution du matériau cible dans une pluralité de chambres d'un dispositif fluidique microfabriqué. Le dispositif fluidique microfabriqué est ensuite manipulé de façon à faire varier l'état de la solution dans les chambres, ce qui permet d'obtenir simultanément un grand nombre d'environnements de cristallisation. Le contrôle des états modifiés de la solution peut résulter de divers techniques, notamment mais pas exclusivement, le mesurage de volumes de l'agent de cristallisation dans la chambre par exclusion de volume, par piégeage de volumes de l'agent de cristallisation déterminé par les dimensions de la structure microfabriqué ou par injection par un canal transversal de l'échantillon et de l'agent de cristallisation dans un ensemble de jonctions définies par l'intersection de canaux d'écoulement orthogonaux.

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