High viscosity liquid composition for the delivery of...

A - Human Necessities – 61 – K

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A61K 47/14 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 9/70 (2006.01) A61K 47/26 (2006.01) A61L 15/44 (2006.01) A61L 24/00 (2006.01) A61L 27/54 (2006.01) C07H 3/02 (2006.01) C07H 15/00 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2382540

The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo, leaving a higher viscosity liquid material.

La présente invention concerne des composés non polymères et des compositions formant des matières liquides à haute viscosité servant à la distribution contrôlée de substances bioactives et à l'utilisation en tant que dispositifs médicaux ou chirurgicaux. Les matières peuvent éventuellement être diluées avec un solvant pour former une matière de viscosité inférieure, rendant ainsi la matière facile à administrer. Ce solvant peut être insoluble ou soluble dans l'eau, le solvant soluble dans l'eau se diffusant et migrant hors de la matière <i>in vivo</i>, ne laissant qu'une matière liquide à haute viscosité.

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