C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/145 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2164946
The present invention relates to influenza virus strains which may reliably be propagated to high titer in hosts such as embryonated eggs. High yield strains, including reassortment influenza viruses and influenza viruses exhibiting chimeric viral surface molecules, such as chimeric HA and/or NA surface molecules, arc described. Further, methods for the production of such high yield influenza A, B, and/or C virus strains are described. These high yield viruses may be used in the production of anti-viral vaccines and the manufacturing of chimeric influenza viruses.
Cette invention concerne des souches de virus de la grippe qu'on peut propager de manière fiable afin d'obtenir une concentration élevée chez des hôtes tels que des oeufs fécondés. Des souches à rendement élevé comprenant des virus de la grippe de réassortiment et des virus de la grippe présentant des molécules de surface virales chimériques, telles que des molécules de surface HA chimériques et/ou des molécules de surface NA sont décrites, ainsi que des procédés de production de ces souches de virus de la grippe A, B, et/ou C à rendement élevé. On peut utiliser ces virus à rendement élevé dans la production de vaccins antiviraux et la production de virus de la grippe chimériques.
Osler Hoskin & Harcourt Llp
Palese Peter
LandOfFree
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