Highly aqueous liquid carrier formulations

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/08 (2006.01) A61K 9/10 (2006.01) A61K 9/72 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2480123

Disclosed is a liquid carrier vehicle for a dissolved or suspended pharmaceutically active agent administered to a patient via inhalation of an aerosol where the aerosol is produced by an electrohydrodynamic spraying device and where the liquid carrier vehicle comprises: a. from about 50% V/V to about 100% V/V water; b. from about 0% to about 40% V/V ethanol; c. from about 0% to about 30% V/V of a co-solvent; d. from about 0.5% to about 10% V/V of a pharmaceutically acceptable excipient; and e. from about 0.05% W/V to about 10% W/V of a derivatized carbohydrate surfactant; wherein said liquid carrier has a resistivity of from about 25ohm m to about 8000 ohm m and a surface tension of from about 20 dyne/cm to about 40 dyne/cm. Also disclosed are liquid compositions comprising the liquid carrier vehicle containing a dissolved or suspended pharmaceutically active agent as well as a method of treating a patient using such liquid compositions.

La présente invention se rapporte à une composition de support liquide destinée à un agent pharmaceutiquement actif dissous ou en suspension administré à un patient par le biais de l'inhalation d'un aérosol. Ledit aérosol est produit au moyen d'un dispositif de pulvérisation électrohydrodynamique et ladite composition de support liquide comprend: a) de 50 % environ en volume à 100 % environ en volume d'eau; b) de 0 % environ à 40 % environ en volume d'éthanol; c) de 0 % environ à 30 % environ en volume d'un cosolvant; d) de 0,5 % environ à 10 % environ en volume d'un excipient pharmaceutiquement acceptable et e) de 0,05 % environ en poids par volume à 10 % environ en poids par volume d'un tensioactif glucidique dérivatisé. Ladite composition de support liquide présente une résistivité comprise entre 25 ohm m et 8000 ohm m environ ainsi qu'une tension surfacique comprise entre 20 dyne/cm environ et 40 dyne/cm environ. L'invention se rapporte également à des compositions liquides qui comportent ladite composition de support liquide contenant un agent pharmaceutiquement actif dissous ou en suspension ainsi qu'à un procédé de traitement d'un patient au moyen de ces compositions liquides.

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