A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/48 (2006.01) A61K 31/19 (2006.01)
Patent
CA 2549731
Concentrated pourable potassium ibuprofen liquid compositions and their preparation are described. They are comprised of (i) potassium ibuprofen, (ii) water; and (iii) methanol, ethanol, 1-propanol, 2-propanol, 1,1- dimethylethanol, or a mixture of any two or more of them. The amount of dissolved potassium ibuprofen in the composition is in the range of about 60 to about 90 wt%. These compositions are suitable for use in the preparation of pharmaceutical dosage form such as liquid-filled soft gelatin capsules, syrups, elixirs, suspensions; solid dosage forms such as tablets or caplets; and topically-applied products such as lotions, creams or ointments.
L'invention concerne des compositions liquides d'ibuprofène de potassium versables concentrées ainsi que la préparation de celles-ci. Ces compositions consistent en (i) ibuprofène de potassium, (ii) eau, et (iii) méthanol, éthanol, 1-propanol, 2-propanol, 1,1-diméthyléthanol, ou un mélange d'au moins deux de ceux-ci. La quantité d'ibuprofène de potassium dissout dans ces compositions est comprise dans la plage allant d'environ 60 à environ 90 % en poids. Ces compositions sont adaptées à une utilisation dans la préparation de doses pharmaceutiques telles que des capsules de gélatine molle remplies de liquide, des sirops, des élixirs, des suspensions, des doses solides telles que des tablettes ou des comprimés-capsules, ainsi que des produits pouvant être appliqués topiquement tels que des lotions, des crèmes ou des onguents.
Hu Patrick C.
Lambeth Gregory H.
Malcolm Arcelio J.
Albemarle Corporation
Macrae & Co.
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