Highly efficient delivery of a large therapeutic mass aerosol

Details Highly efficient delivery of a large therapeutic mass aerosol Highly efficient delivery of a large therapeutic mass aerosol

A - Human Necessities

61

K

A61K 9/72 (2006.01) A61M 15/00 (2006.01)

Patent

CA 2412561

A method for delivering an agent to the pulmonary system, in a single, breath- activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50 % of the mass of particles. The particles are capable of carrying agents. The agent is: 1) part of the spray-drying pre-mixture and thereby incorporated into the particles; 2) added to separately-prepared particles so that the agent is in chemical association with the particles; or 3) blended so that the agent is mixed with, and co-delivered with the particles. Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.

L'invention concerne un procédé de distribution d'un agent au système pulmonaire, en une seule phase activée par la respiration, ou en une seule respiration consistant à administrer, dans les voies respiratoires d'un sujet, des particules dont la densité après tassement est inférieure à 0,4 g/cm?3¿, et à distribuer au moins environ 50 % de la masse particulaire à partir d'un réceptacle renferment ladite nmasse particulaire Les particules peuvent porter des agents. L'agent est 1) constitué d'une partie d'un pré-mélange séché par pulvérisation, puis incorporé dans les particules; 2) ajouté à des particules préparées séparément de sorte qu'il est associé chimiquement avec lesdites particules; ou 3) mélangé avec les particules, et distribué conjointement avec celles-ci. L'invention concerne également des compositions respirables comprenant des particules de support dont la densité de tassement est inférieure à 0,4 g/cm?3¿, et une composition comprenant un agent. L'invention concerne enfin des procédés permettant de distribuer lesdites compositions respirables.

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