Highly efficient dendritic cell-targeted dna-vaccination

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 39/145 (2006.01) C07K 14/11 (2006.01) C07K 14/705 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2404709

The present invention relates to a vaccine containing a nucleic acid molecule comprising (a) a promoter that is specifically active in antigen presenting cells; and, operatively linked thereto (b) a nucleic acid sequence encoding an antigen. The present invention also relates to a method of vaccinating a mammal wherein the vaccine of the invention is administered to a mammal at a suitable dose.

La présente invention concerne un vaccin contenant une molécule d'acide nucléique comprenant: (a) un promoteur spécifiquement actif dans les cellules présentatrices d'antigène; et, fonctionnellement reliée au promoteur précité, (b) une séquence nucléotidique codant un antigène. L'invention se rapporte également à un procédé de vaccination d'un mammifère selon lequel on administre à un mammifère une dose adéquate du vaccin de l'invention.

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