Highly plastic granules for making fast melting tablets

Details Highly plastic granules for making fast melting tablets Highly plastic granules for making fast melting tablets

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2524806

A fast-melting pharmaceutical tablet comprises a plastic substance, a water penetration enhancer and a binder. One or more drugs can be incorporated into the formulation at different stages of the process so as to afford a pharmaceutically active tablet. Methods of making the pharmaceutical tablet entail combining the plastic material, the water penetration enhancing agent, and the binder so as to form highly plastic granules, which are compressed into tablets. The resulting tablets dissolve rapidly in the mouth and have good hardness with low brittleness. The tablets are particularly valuable to those who have difficulty swallowing conventional pills.

L'invention concerne un comprimé pharmaceutique à dissolution rapide comprenant une substance plastique poreuse, un activateur de pénétration d'eau et un liant. Un ou plusieurs médicaments peuvent être incorporés dans la préparation, à différentes étapes du processus, pour fournir un comprimé de qualité pharmaceutique. L'invention concerne également des procédés destinés à la fabrication de ce comprimé pharmaceutique, consistant à mélanger la substance plastique poreuse, l'agent activateur de pénétration d'eau et le liant pour former des granules à teneur élevée en plastique qui sont compressés en tablettes comprimées. Les comprimés obtenus se dissolvent rapidement dans la bouche, présentent une bonne dureté et une faible friabilité. Ces comprimés sont tout particulièrement destinés aux personnes ayant des difficultés à avaler des comprimés classiques.

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