Highly purified type a botulinum toxin preparation from...

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) A61K 47/42 (2006.01) A61P 1/00 (2006.01) A61P 7/12 (2006.01) A61P 17/00 (2006.01) A61P 21/02 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/06 (2006.01) A61P 25/16 (2006.01) A61P 27/02 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2667536

It is intended to provide a novel botulinum toxin type A preparation. An inhibitor of neuromuscular transmission containing a highly purified botulinum toxin type A derived from Clostridium botulinum causing infant botulism as an active ingredient, and a therapeutic agent for hypertonia disease containing the toxin as an active ingredient. In particular, because having an immediate effect and low diffusibility compared with a conventionally known botulinum toxin preparation, this preparation has a wide safety margin and is suitable to be used as a therapeutic agent for lowering a local increase in muscle tone in hypertonia disease.

L'invention concerne une nouvelle préparation de toxine botulinique de type A, un inhibiteur de transmission neuromusculaire qui contient une toxine botulinique hautement purifiée de type A issue de Clostridium botulinum provoquant le botulisme chez l'enfant en tant qu'ingrédient actif, et un agent thérapeutique pour une maladie d'hypertonie contenant la toxine en tant qu'ingrédient actif. En particulier, en raison du fait qu'elle a un effet immédiat et une diffusibilité faible en comparaison d'une préparation de toxine botulinique connue de façon classique, cette préparation possède une marge de sécurité large et est appropriée pour être utilisée en tant qu'agent thérapeutique de manière diminuer une augmentation locale de tonicité musculaire dans la maladie d'hypertonie.

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