Highly reactive esters of carboxy polysaccharides and novel...

C - Chemistry – Metallurgy – 08 – B

Patent

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Details

C08B 37/00 (2006.01) A61K 47/48 (2006.01) C07K 9/00 (2006.01) C08B 37/08 (2006.01)

Patent

CA 2184899

Provided are active esters of carboxy polysaccharides and semisynthetic derivatives of carboxy polysaccharides, wherein all or part of the carboxy groups thereof are esterified with an aromatic alcohol, a substituted aromatic alcohol, an aromatic heterocyclic alcohol, a substituted aromatic heterocyclic alcohol, an N-hydroxylamine, or a combination thereof. Also provided is a process for producing such active esters. These active esters can be used for the preparation of modified carboxy polysaccharides or modified semisynthetic derivatives of such carboxy polysaccharides, in the form of esters, thioesters, or amides. Such active esters, modified polysaccharides, and modified semisynthetic derivatives of carboxy polysaccharides can be used in the biomedical and pharmaceutical fields to prepare, for example, cosmetic articles, health care articles, surgical articles, and diagnostic kits.

L'invention se rapporte à des esters actifs de carboxy polysaccharides et à des dérivés semi-synthétiques de carboxy polysaccharides dans lesquels tout ou partie des groupes carboxy de ceux-ci sont estérifiés avec un alcool aromatique, un alcool aromatique substitué, un alcool hétérocyclique aromatique, un alcool hétérocyclique aromatique substitué, une N-hydroxylamine, ou une combinaison de ceux-ci. L'invention se rapporte également à un procédé de production de ces esters actifs. Ces esters actifs peuvent être utilisés dans la préparation de carboxy polysaccharides modifiés ou de dérivés semi-synthétiques modifiés de ces carboxy polysaccharides, sous la forme d'esters, de thioesters, ou d'amides. Ces esters actifs, ces polysaccharides modifiés et ces dérivés semi-synthétiques modifiés de carboxy polysaccharides peuvent être utilisés dans les domaines biomédicaux et pharmaceutiques pour préparer, par exemple, des articles cosmétiques, des articles de soin, des articles chirurgicaux et des kits de diagnostic.

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