Highly reflective biogratings and method

G - Physics – 01 – N

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G01N 33/552 (2006.01) G01N 21/47 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2081776

2081776 9118292 PCTABS00008 A reflective biograting consists of an optically flat layer of a transparent composition such as silicon dioxide having a first and second surface, spatially periodic zones of active and inactive binding agent on the first surface, and a reflective metal layer having a thickness sufficient to prevent transmission of substantially all light therethrough. The reflective metal layer can be supported on an optically flat surface of metal wafer, and the reflective metal can be aluminum, silver, gold, chromium, nickel, titanium or platinum coating on a polished wafer. Preferably, the silicon dioxide layer is formed either by direct sputtering of silicon dioxide or by coating an alkali metal silicate solution on the surface of the reflective metal, optionally containing an aminoalkysilane and a water-soluble hydroxylated polymer such as a dextran. Alternatively, the reflective support comprises a multilayer dielectric mirror on an optically flat surface.

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