C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/06 (2006.01) A61K 31/553 (2006.01) A61P 3/06 (2006.01) C07C 51/06 (2006.01) C07C 231/02 (2006.01) C07D 267/14 (2006.01)
Patent
CA 2569686
The present invention provides an industrial production method with a short process having a high yield of an aliphatic cyclic carboxamide having carboxyl group, which comprises reacting functional group-selectively using an inexpensive condensing agent without protecting the carboxyl group by esterification, that is, reacting carboxylic acid anhydride obtained by reacting carboxylic acid and tertiary carboxylic acid halide with aliphatic cyclic secondary amine having carboxyl group.
La présente invention fournit un procédé de production industrielle avec un procédé court qui a un rendement élevé d~un carboxamide cyclique aliphatique comportant un groupe carboxyle, qui comprend la mise en réaction de façon sélective d~un groupe fonctionnel en utilisant un agent de condensation peu coûteux sans protéger le groupe carboxyle par estérification, c~est-à-dire, en faisant réagir un anhydride d~acide carboxylique obtenu en faisant réagir un acide carboxylique et un halogénure d~acide carboxylique tertiaire avec une amine secondaire cyclique aliphatique comportant un groupe carboxyle.
Inagaki Atsushi
Sera Misayo
Fetherstonhaugh & Co.
Takeda Pharmaceutical Company Limited
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