A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 35/14 (2006.01)
Patent
CA 2615328
Disclosed are antibodies that selectively bind to blood coagulation factor FVIII and highly sensitive immunological assays comprising these antibodies. Preferred assays can detect FVIII at about 3500-fold below the normal physiological levels, and have a wide array of applications including accurate monitoring of FVIII concentration in pharmaceutical products for treatment of blood coagulation disorders, and determination of FVIII levels in plasma of human patients, including those with blood coagulation disorders such as hemophilia.
L'invention concerne des anticorps qui se lient sélectivement avec le facteur VIII de la coagulation du sang et des essais immunologiques ultrasensibles contenant ces anticorps. Les essais préférés sont capables de détecter le FVIII à des taux 3500 fois inférieurs aux taux physiologiques normaux, et présentent un large éventail d'applications, notamment le contrôle précis de la concentration de FVIII dans les produits pharmaceutiques destinés au traitement des troubles de la coagulation sanguine, et la détermination des taux de FVIII dans le plasma de patients humains, notamment ceux présentant des troubles de la coagulation sanguine tels que l'hémophilie.
Fass David N.
Mann Kenneth G.
Parhami-Seren Behnaz
Borden Ladner Gervais Llp
The University Of Vermont And State Agriculture College
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