A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/715 (2006.01) A61K 31/70 (2006.01) A61K 31/737 (2006.01) C07H 11/00 (2006.01)
Patent
CA 2171465
A novel class of highly sulfated maltooligosaccharides having heparin- like activity is described, a well as methods for using these oligosaccharides to treat certain diseases including cancer, retinopathies and cardiovascular diseases. The figure shows the effects of the degree of sulfation of certain maltooligosaccharides, on binding of a lymphoblastoid cell line transfected with hamster syndecan (RO-12 UC) cells, to microtiter wells coated with basic fibroblast growth factor (bFGF).
L'invention concerne une nouvelle catégorie de maltooligosaccharides fortement sulfatées présentant des propriétés semblables à l'héparine. L'invention traite également de procédés permettant d'utiliser ces oligosaccharides pour traiter certaines maladies dont le cancer, les rétinopathies, et les maladies cardiovasculaires. La figure illustre les effets du degré de sulfatage de certains maltooligosaccharides, sur la liaison d'une lignée cellulaire lymphoblastoïde transfectée avec des cellules (RO-12 UC) de syndécan d'hamster avec des cupules de microtitrage recouvertes d'un facteur de croissance de fibroblastes basique.
Fugedi Peter
Ishihara Masayuki
Stack Robert Joseph
Tressler Robert James
Tyrrell David John
Glycomed Incorporated
Smart & Biggar
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