C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01)
Patent
CA 2671825
The invention relates to a method for obtaining a cell line, that comprises the steps of integrating into the genome of said cell a unique site for the recognition of a recombinase in an area of high transcription activity of the genome of said cell, and integrating in the genome of said cell, and downstream from the unique recombinase recognition site, a nucleic acid sequence coding for a transcription termination signal. The invention also relates to cell lines obtained by said method.
L'invention, concerne un procédé d'obtention d'une lignée cellulaire comprenant les étapes consistant à intégrer dans le génome de ladite cellule un site unique de reconnaissance d'une recombinase dans une zone de forte activité transcriptionnelle du génome de ladite cellule; et intégrer, dans le génome de ladite cellule, en aval du site unique de reconnaissance d'une recombinase, une séquence d'acide nucléique codant un signal de terminaison de la transcription. L'invention concerne également les lignées cellulaires obtenues par ce procédé.
Gaucher Christine
Sirac Christophe
Gowling Lafleur Henderson Llp
Lfb Biotechnologies Societe Par Actions Simplifiee Unipersonnell
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