Hindered aromatic ester compounds useful as anti-viral agents

Details Hindered aromatic ester compounds useful as anti-viral agents Hindered aromatic ester compounds useful as anti-viral agents

C - Chemistry, Metallurgy

07

C

C07C 233/81 (2006.01) A61K 31/245 (2006.01) A61K 31/265 (2006.01) A61K 31/33 (2006.01) C07C 327/26 (2006.01) C07C 327/48 (2006.01) C07D 207/34 (2006.01) C07D 231/14 (2006.01) C07D 291/06 (2006.01) C07D 307/68 (2006.01) C07D 327/06 (2006.01) C07D 333/38 (2006.01) C07D 339/08 (2006.01)

Patent

CA 2163174

Compounds of the formula (see formula I) wherein X is O or S; Y is O or S; R1 is hydrogen, halogen, C1-C4 alkyl or C1-C4 alkoxy; R2 is hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C2-C4 alkenyl, C2-C4 alkenyloxy, C2-C4 alkynyl, C2-C4 alkynyloxy, mono-, di- or tri-halomethyl, trifluoromethoxy, C1-C4 alkylthio, C3-C4 branched alkylthio, nitro, or cyano; R3 is hydrogen, halogen, methyl, mono-, di- or tri- halomethyl; R4 is a) C3-C8 cycloalkyl substituted by one or more C1-C4 alkyl, preferably one or two methyl; or b) (see formula II) wherein R6 and R7 are independently, hydrogen or linear or branched, C1-C4 alkyl, C2-C4 alkenyl, or C2-C4 alkynyl, and R8 is C3-C8 cycloalkyl substituted by one or more C1-C4 alkyl; and R5 is an acyclic or cyclic side chain as defined herein. These compounds are useful for inhibiting the growth or replication of retroviruses such as HIV.

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