Hirudin analog, method of manufacturing thereof and...

Details Hirudin analog, method of manufacturing thereof and... Hirudin analog, method of manufacturing thereof and...

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) C07K 14/815 (2006.01) C12N 1/21 (2006.01) C12N 15/55 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01)

Patent

CA 2255396

Provided is a chimeric HV1/HV3 hirudin analog useful as an anti-coagulant, exhibiting higher anti-thrombin activity and less tendency to cause bleeding than hirudin HV1. Also provided are a method of producing hirudins and hirudin analogs, as well as other proteins, employing secretion vectors, and transformed microorganisms such as E. coli. Pharmaceutical compositions comprising various hirudins or the chimeric HV1/HV3 hirudin analog of the present invention and a pharmaceutically acceptable carrier are also disclosed.

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