Hirudin-coated biocompatible substance

Details Hirudin-coated biocompatible substance Hirudin-coated biocompatible substance

A - Human Necessities

61

L

167/326

A61L 33/00 (2006.01) A61L 33/12 (2006.01)

Patent

CA 1338756

Disclosed is a biocompatible, thrombo- resistant substance useful for implantable and extracorporeal devices in contact with the vascular system, and methods for producing the same. The biocompatible, thromboresistant substance comprises a synthetic, biocompatible material, at least one biocompatible base coat layer adhered to at least one surface of the material, and a thrombogenesis inhibitor immobilized on the base coat layer via a component capable of binding the inhibitor. The thrombogenesis inhibitor is hirudin, or an active analog or fragment thereof.

607503

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