Hirudin conjugates from hirudin and lipophilic compounds

Details Hirudin conjugates from hirudin and lipophilic compounds Hirudin conjugates from hirudin and lipophilic compounds

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/58 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2176967

The invention pertains to new hirudin conjugates formed from a hirudin and one more lipophilic compounds, where the lipophilic compound has an octanol-water distribution coefficient of more than 1.8 and is chemically bonded to the hirudin. The invention also pertains to the preparation and use of these conjugates.

L'invention concerne de nouveaux conjugués d'hirudine comprenant de l'hirudine et un ou plusieurs composés lipophiles. Le composé lipophile présente un coefficient de répartition octanol-eau de plus de 1,8 et est lié chimiquement avec l'hirudine. L'invention concerne en outre la préparation et l'utilisation de tels conjugués.

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