Histamine derivatives and methods for their use as...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 233/88 (2006.01) A61K 31/415 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/35 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2128516

2128516 9314754 PCTABS00024 The present invention provides methods for using histamine derivatives as immunomodulators and in immunotherapeutics. More specifically the present invention provides methods for inhibiting at least a portion of an antigen specific antibody response and/or a portion of a T cell proliferative response by the immune system of a mammal comprising administering to said mammal an effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor. The invention also pertains to methods of treating sensitivity to a particular antigen and methods of treating T cell mediated disease in a person by administering to the person a therapeutically effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor, optionally administering to the person the antigen or an immunogenic portion thereof and further optionally administering to the person a peptide comprising at least one T cell epitope of said antigen.

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