Histamine h3 inverse agonists and antagonists and methods of...

Details Histamine h3 inverse agonists and antagonists and methods of... Histamine h3 inverse agonists and antagonists and methods of...

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/551 (2006.01) A61P 25/28 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2752073

Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

L'invention porte sur des composés imidazolylés fusionnés, sur des procédés de synthèse et sur des procédés d'utilisation correspondants. Les composés fournis dans la description sont utiles pour le traitement, la prévention et/ou la gestion de divers troubles, tels que des troubles neurologiques et des troubles métaboliques. Les composés fournis dans la description inhibent l'activité des récepteurs de l'histamine H3 et modulent la libération de divers neurotransmetteurs, tels que l'histamine, l'acétylcholine, la norépinéphrine et la dopamine (par exemple au niveau de la synapse). L'invention porte également sur des formulations pharmaceutiques contenant les composés et sur leurs procédés d'utilisation.

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