C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/09 (2006.01) A61K 31/4025 (2006.01) A61P 3/04 (2006.01) A61P 25/28 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2613192
The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.
L'invention se rapporte à de nouveaux composés de la formule 1 ou à des sels pharmaceutiquement acceptables de ces derniers qui possèdent une activité antagoniste ou agoniste inverse du récepteur à l'histamine H3, et à des procédés de préparation desdits composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant des composés de la formule 1, et des procédés d'utilisation de ces derniers pour traiter l'obésité, les déficiences cognitives, la narcolepsie et d'autres affections liées au récepteur de l'histamine H3.
Beavers Lisa Selsam
Finley Don Richard
Gadski Robert Alan
Hipskind Philip Arthur
Hornback William Joseph
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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