Histamine h3 receptor agents, preparation and therapeutic uses

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 207/09 (2006.01) A61K 31/00 (2006.01) A61K 31/4025 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 405/10 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2561628

The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases

La présente invention se rapporte à de nouveaux composés représentés par la formule (I) ou à des sels pharmaceutiquement acceptables de ces composés qui possèdent une activité agoniste inverse ou antagoniste des récepteurs de l'histamine-H3, ainsi qu'à des procédés de préparation de ces composés. Dans un autre mode de réalisation, l'invention se rapporte à des compositions pharmaceutiques comportant des composés représentés par la formule (I) ainsi qu'à des procédés d'utilisation de ces compositions pour traiter l'obésité, les déficiences cognitives, la narcolepsie ainsi que d'autres maladies associées aux récepteurs de l'histamine H3.

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