Histamine h3 receptor agents, preparation and therapeutic uses

Details Histamine h3 receptor agents, preparation and therapeutic uses Histamine h3 receptor agents, preparation and therapeutic uses

C - Chemistry, Metallurgy

07

D

C07D 409/10 (2006.01) A61K 31/4025 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 405/10 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/10 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2577061

The present invention provides a novel compound of Formula (I) or a pharmaceutically acceptable salt thereof, having histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another, embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.

La présente invention concerne un composé nouveau de la formule (I) ou un sel pharmaceutiquement acceptable de celui-ci qui possède une activité antagoniste ou agoniste inverse des récepteurs de l~histamine H3, ainsi que des procédés de préparation d'un tel composé. Dans un autre mode de réalisation, l~invention décrit des compositions pharmaceutiques qui comprennent des composés de la formule (I) ainsi que des procédés d~utilisation de ces compositions pour traiter l~obésité, les déficiences cognitives, la narcolepsie, ainsi que d~autres maladies liées aux récepteurs de l~histamine H3.

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