Histamine h3 receptor agents, preparation and therapeutic uses

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 207/09 (2006.01) A61K 31/4025 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2602234

The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using these compositions to treat obesity, cognitive deficiencies, narcolepsy, and other histamine H3 receptor-related diseases.

La présente invention concerne de nouveaux composés selon la formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci qui ont une activité d'antagoniste du récepteur H3 de l'histamine ou une activité agoniste inverse, de même que des procédés et produits intermédiaires pour préparer de tels composés. Dans un autre mode de réalisation, l'invention présente des compositions pharmaceutiques comprenant des composés selon la formule (I) de même que des procédés utilisant ces compositions destinés à traiter l'obésité, les déficiences cognitives, la narcolepsie et d'autres maladies liées au récepteur H3 de l'histamine.

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