Histamine h3 receptor antagonists

Details Histamine h3 receptor antagonists Histamine h3 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/444 (2006.01) A61P 3/00 (2006.01) C07D 213/84 (2006.01) C07D 213/87 (2006.01) C07D 241/20 (2006.01) C07D 401/04 (2006.01) C07D 401/08 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2614116

Novel compounds which interact with the histamine H3 receptor are defined. These compounds are particularly useful in the treatment of a variety of diseases or conditions in which histamine H3 interactions are beneficial. Thus, the compounds may find use, e.g., in the treatment of diseases of the central nervous system, the peripheral nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system. The novel compounds have a core consisting of a 6 membered aromatic ring containing at least one nitrogen atom and two carbon atoms in the ring and, at the remaining positions in the ring, there is either a carbon or a nitrogen atom.

L'invention concerne des composés interagissant avec le récepteur de l'histamine H3. Ces composés sont particulièrement utiles dans le traitement d'une palette de maladies ou d'états dans lesquels les interactions de l'histamine H3 sont bénéfiques. Par conséquent, les composés peuvent être utiles, par exemple, dans le traitement de maladies du système nerveux central, du système nerveux périphérique, du système cardio-vasculaire, du système pulmonaire, du système gastro-intestinal et du système endocrinologique. Les composés comprennent un noyau présentant un anneau aromatique à 6 chaînons renfermant au moins un atome d'azote et deux atomes de carbone dans l'anneau et, au niveau des positions restantes dans l'anneau, soit un carbone, soit un atome d'azote.

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