Histamine receptor h3 polynucleotides

Details Histamine receptor h3 polynucleotides Histamine receptor h3 polynucleotides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2467347

Novel splice variants of the human H3 histamine receptor are described. The splice variants have deletions of portions of the N-terminal of the wild type H3 receptor. The splice variants are useful in methods for identifying agonists, inverse agonists or antagonists of histamine action at the H3 receptor.

La présente invention concerne des variantes à épissage du récepteur histaminique H3 chez l'homme. Ces variantes à épissage présentent des suppressions de parties de la terminaison N du récepteur H3 de type sauvage. Ces variantes à épissage conviennent pour des procédés visant à identifier des agonistes, des agonistes inverses ou des antagonistes de l'action de l'histamine au niveau du récepteur H3.

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