Histidine-containing diastereomeric peptides and uses thereof

Details Histidine-containing diastereomeric peptides and uses thereof Histidine-containing diastereomeric peptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/00 (2006.01) A61K 38/10 (2006.01) A61K 38/12 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2635456

Diastereomeric peptides with a net positive charge greater than +1, and cyclic derivatives thereof, are provided, having at least 13 amino acid residues, comprising histidine and one or more hydrophobic amino acid residues, optionally esterified or amidated at the C-terminus and/or acylated at the N- terminus. The peptides may contain other amino acid residues including non- natural amino acids. The peptides are particularly useful in the treatment of cancer.

La présente invention concerne des peptides diastéréomères dont la charge positive nette est supérieure à +1 et leurs dérivés cycliques, les peptides comprenant au moins 13 résidus d'acides aminés, dont l'histidine et un ou plusieurs résidus d'acides aminés hydrophobes, facultativement à extrémité C estérifiée ou amidée et/ou à extrémité N acylée. Les peptides peuvent contenir d'autres résidus d'acides aminés, y compris des acides aminés non naturels. Les peptides sont particulièrement utiles pour le traitement du cancer.

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