Histidine decarboxylase inhibitors

Details Histidine decarboxylase inhibitors Histidine decarboxylase inhibitors

A - Human Necessities

61

K

167/246

A61K 31/00 (2006.01) A61K 31/235 (2006.01) A61K 31/60 (2006.01)

Patent

CA 1050888

HISTIDINE DECARBOXYLASE INHIBITORS Abstract of the Disclosure Compounds having the general formula Image wherein R1 is OH or Image in which Y is lower alkyl or phenyl; R2 is substituted either at the 4 -position or at the 5 - position and is hydrogen, fluoro, bromo, chloro, hydroxy, lower alkyl or Image in which Y is lower alkyl or phenyl; R3 is chloro, bromo or lower alkyl; R4 is hydroxy, amino, low r alkoxy or Image in which Y is lower alkyl or phenyl-; R5 is hydrogen, fluoro, bromo, chloro, carboxyl, lower alkyl or Image in which Z is lower alkyl; and the nontoxic, pharmaceutically acceptable metal-salts of said compound in which R5 is carboxyl; and the pharmaceutically acceptable salts and esters thereof exhibit strong activities in inhibiting histidine decarboxylase and xanthine oxidase. One example is the compound of the formula Image

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