Histidine protein-phosphatase

Details Histidine protein-phosphatase Histidine protein-phosphatase

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 38/46 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2364495

The invention relates to a novel enzyme, histidine protein phosphatase, which is derived from mammalian sources, and its homologue variants. The invention further relates to DNA sequences encoding said proteins, to a process for preparing the latter, and to antibodies directed against them. The novel phosphatase can be used for diagnosis of pathological states of cell regulation and cell growth and as pharmaceutical drug which can be administered in conjunction with pathological disorders related to malfunctions of said enzyme.

Cette invention se rapporte à une nouvelle enzyme, l'histidine protéine phosphatase, qui est dérivée de sources mammifères, ainsi qu'à ses variants homologues. Cette invention se rapporte également à des séquences d'ADN codant de telles protéines, à un procédé de préparation de celles-ci et à des anticorps dirigés contre celles-ci. Cette nouvelle phosphatase peut être utilisée dans le diagnostic de conditions pathologiques de la régulation cellulaire et de la croissance cellulaire et comme produit pharmaceutique pouvant être administré en association avec des troubles pathologiques relatifs à des dysfonctionnements de cette enzyme.

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