Histidine-rich glycoprotein

Details Histidine-rich glycoprotein Histidine-rich glycoprotein

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61K 38/21 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2436340

The invention relates to histidine-rich glycoprotein (HRGP) polypeptides and the use of these polypeptides. The invention includes methods for the inhibition of angiogenesis by administering an HRGP polypeptide. The invention also includes pharmaceutical compositions and articles of manufacture comprising HRGP polypeptides, antibodies and receptors that bind to an HRGP polypeptide, HRGP-depleted plasma and polynucleotides, vectors and host cells that encode HRGP polypeptides.

L'invention concerne des polypeptides de glycoprotéine riche en histidine (HRGP), ainsi que l'utilisation de ces polypeptides. L'invention concerne également des procédés d'inhibition de l'angiogenèse par administration d'un polypeptide HRGP. L'invention concerne en outre des compositions pharmaceutiques et des articles de fabrication comprenant des polypeptides HRGP, des anticorps et des récepteurs se liant à un polypeptide HRGP, un plasma et des polynucléotides dépourvus d'HRGP, des vecteurs et des cellules hôtes codant pour des polypeptides HRGP.

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