C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/16 (2006.01) C07K 16/40 (2006.01) C12N 9/18 (2006.01) C12N 15/55 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2393725
The present invention is directed to novel nucleic acids that encode novel HDAC proteins, which have an affect on chromating structure and transcription. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods of producing the polypeptides of the present invention. Further provided by the present invention are methods of identifying novel compositions which mediate HDAC8 and the use of such compositions in diagnosis and treatment of disease.
La présente invention concerne des acides nucléiques codant pour des protéines HDAC, qui ont un effet sur la transcription et la structure de la chromatine. Cette invention concerne aussi des vecteurs et des cellules hôtes comprenant ces séquences d'acides nucléiques, des molécules de polypeptides chimériques comprenant les polypeptides de cette invention fusionnés avec des séquences de polypeptides hétérologues, des anticorps qui se lient aux polypeptides de cette invention, et des techniques de production de ces polypeptides. Cette invention concerne enfin des techniques de recherche de compositions qui induisent HDAC8 et l'utilisation de ces compositions dans le diagnostic et le traitement de maladie.
Axys Pharmaceuticals Inc.
Pharmacyclics Inc.
Smart & Biggar
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