Histone deacetylase (hdac) inhibitors (pxdlol) for the...

A - Human Necessities – 61 – K

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A61K 31/10 (2006.01) A61K 31/196 (2006.01) A61K 31/475 (2006.01) A61K 31/573 (2006.01) A61K 31/65 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2627923

The present invention relates generally to methods for treating cancer. In one respect, the present invention relates to a method of treating a hematological cancer (e.g., multiple myeloma, leukemia, lymphoma) comprising administering to a patient in need thereof a therapeutically effective amount of a histone deacetylase inhibitor, for example, a histone deacetylase (HDAC) inhibitor as described herein, for example, PXD-101. In another respect, the present invention relates to a method of treating cancer (e.g., solid tumour cancer, e.g., rectal cancer, colon cancer, ovarian cancer; hematological cancer, e.g., multiple myeloma, leukemia, lymphoma) comprising administering to a patient in need thereof, a first amount of a histone deacetylase (HDAC) inhibitor, for example, a histone deacetylase inhibitor as described herein, for example, PXD- 101 , and a second amount of an other chemotherapeutic agent, for example, an other chemotherapeutic agent selected from: an antibody against VEGF, Avastin~, an antibody against CD20, rituximab, bortezomib, thalidomide, dexamethasone, vincristine, doxorubicin, and melphalan, wherein the first and second amounts together comprise a therapeutically effective amount.

La présente invention concerne, de manière générale, des méthodes de traitement du cancer. Selon un aspect, la présente invention concerne une méthode de traitement d'un cancer hématologique (par ex., myélome multiple, leucémie, lymphome) consistant à administrer à un patient en attente dudit traitement une quantité thérapeutiquement efficace d'un inhibiteur d'histone désacétylase, par exemple, d'un inhibiteur d'histone désacétylase (HDAC) tel que décrit dans l'invention, par exemple, un PXD-101. Selon un autre aspect, la présente invention concerne une méthode de traitement du cancer (par ex., cancer à tumeurs solides, par ex., cancer rectal, cancer du côlon, cancer des ovaires, cancer hématologique, par ex., myélome multiple, leucémie, lymphome) consistant à administrer à un patient en attente dudit traitement, une première quantité d'un inhibiteur d'histone désacétylase (HDAC), par exemple, d'un inhibiteur d'histone désacétylase tel que décrit dans l'invention, par exemple, un PXD-101, ainsi qu'une seconde quantité d'un autre agent chimiothérapeutique, par exemple, un autre agent chimiothérapeutique sélectionné parmi: un anticorps anti-VEGF, l'Avastine®, un anticorps anti-CD20, le rituximab, le bortézomib, la thalidomide, la dexaméthasone, la vincristine, la doxorubicine et le melphalan, les première et seconde quantités comprenant ensemble une quantité thérapeutiquement efficace.

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