Histone deacetylase inhibitors

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 275/04 (2006.01) A61K 31/17 (2006.01) A61K 31/426 (2006.01) C07C 275/20 (2006.01) C07C 275/26 (2006.01) C07C 275/28 (2006.01)

Patent

CA 2573413

This invention relates to hydroxamic acid derivatives having a urea linkage, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and inflammatory diseases, diseases of the central nervous system (CNS) such as neurodegenerative diseases, and in the prevention and/or treatment of restenosis.

Cette invention concerne des dérivés de l'acide hydroxamique ayant une liaison urée, lesquels sont des inhibiteurs de l'histone désacétylase (HDAC) et sont utiles dans la prévention et/ou le traitement de maladies prolifératives des cellules, par exemple du cancer, de maladies autoimmunes, allergiques et inflammatoires, de maladies du système nerveux central (SNC) telles que des maladies neurodégénératives et dans la prévention et/ou le traitement de la resténose.

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